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2023
Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids
Pelin Saglam-Metiner, Utku Devamoglu, Yagmur Filiz, Soheil Akbari, Goze Beceren, Bakiye Goker, Burcu Yaldiz, Sena Yanasik, Cigir Biray Avci, Esra Erdal, Ozlem Yesil-Celiktas
We demonstrate two different engineering approaches, the rotating cell culture system (RCCS) microgravity bioreactor and a newly designed microfluidic platform (µ-platform) to improve harvestability, reproducibility and the survival of high-quality cerebral organoids and compare with those of traditional spinner and shaker systems.
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2022
Supercritical carbon dioxide dried double layer laponite XLS and alginate / polyacrylamide construct and immune response
Yagmur Filiz, PelinSaglam-Metiner, Seymanur Ersoy, OzlemYesil-Celiktas
In this study, a double layer hydrogel was successfully synthesized, where alginate/polyacrylamide were formulated to represent cartilage layer (5–10 % (w/w) total polymer ratio) and laponite XLS (2−5-8% (w/w))/alginate/polyacrylamide formed bone layer.
2021
An alginate-poly (acrylamide) hydrogel with TGF-β3 loaded nanoparticles for cartilage repair: Biodegradability, biocompatibility and protein adsorption
Ecem Saygili, Elif Kaya, Esra Ilhan-Ayisigi, Pelin Saglam-Metiner, Emine Alarcin, Aslihan Kazana, Ezgi Girgic, Yong-Woo Kim, Kasim Gunes, Guler Gamze Eren-Ozcan, Dilek Akakin, Jeong-Yun Sun, OzlemYesil-Celiktas
Here, we report a holistic and interdisciplinary approach for cartilage tissue engineering to design DN hydrogel-based cartilage implants by using Alg and PAAm polymer networks.
2020
A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles
Fatemeh Sharifi, Ozlem Yesil-Celiktas, Aslihan Kazan, Sushila Maharjan, Saghi Saghazadeh, Keikhosrow Firoozbakhsh, Bahar Firoozabadi & Yu Shrike Zhang
HCC–bone metastasis-on-a-chip platform was demonstrated to model certain key aspects of the cancer metastasis process, hence corroborating the potential of enabling investigations on metastasis-associated biology as well as improved anti-metastatic drug screening.
2019
A foreign body response‐on‐a‐chip platform
Fatemeh Sharifi,Su Su Htwe,Martina Righi,Hua Liu,Anna Pietralunga,Ozlem Yesil-Celiktas,Sushila Maharjan,Byung-Hyun Cha,Su Ryon Shin,Mehmet Remzi Dokmeci,Nihal Engin Vrana,Amir M. Ghaemmaghami,Ali Khademhosseini,Yu Shrike Zhang
Here, we report the development of a physiologically relevant and microscopy-friendly in vitro microfluidic platform, the FBR-on-a-chip (FBROC), to reproduce the dynamic effects of circulating immune cells on the implant occurring in FBR.
2018
Advances in glioblastoma multiforme treatment: new models for nanoparticle therapy
In this paper, we critically summarize current glioblastoma therapy, with a focus on emerging nanomedicine and therapies that capitalize on cell-specific signaling in glioblastoma. We follow this summary by discussing computational modeling approaches focused on optimizing these emerging nanotherapeutics for brain cancer.
Ege University
Department of Bioengineering
35040 Bornova-Izmir/TURKEY