The cellular microenvironment regulates cell behavior and functions. Mimicking this microenvironment in vitro is very challenging both studying physiology and pathology. From the perspective of physiology, microfluidic platforms are developed which modeled the structure and function of human organs, particularly to predict drug safety in humans rapidly and effectively. More recently, disease modeling using organ-on-chip platforms to recapitulate the tissue functions at organ level has been utilized to have a deeper understanding of various diseases. Although animal models have been used to follow up critical diseases, it is often difficult to simulate these models to human physiology. Hence, our lab focused on the convergence of life sciences, engineering, and basic sciences in order to mimic physiological systems of biological organs such as the brain, liver and lung in vitro.